Machine for the preparation of pharmaceutical products

ABSTRACT

A machine for the preparation of pharmaceutical products is provided with a gripping and carrier device to transfer at least one container between a magazine and a dosage station for the preparation of a pharmaceutical product, and a box-type holding frame defining a chamber for the housing of magazine, gripping and carrier device, and dosage station; the chamber displaying an access aperture to magazine and being crossed by a sterile air flow adapted to avoid the entry of air from the external environment through aperture itself.

TECHNICAL FIELD

The present invention relates to a machine for the preparation ofpharmaceutical products.

Specifically, the present invention relates to a machine for thepreparation of toxic pharmaceutical products as, for example, cytostaticdrugs for chemotherapy, to which the following description willexplicitly refer without thereby departing from generality.

BACKGROUND ART

In the field of the preparation of cytostatic drugs, a machine is knowncomprising a magazine for a plurality of containers; a dosage stationfor the preparation of a pharmaceutical product obtained by mixing atleast one cytostatic pharmaceutical compound and at least one diluentcontained in corresponding containers; and a gripping and carrier deviceto transfer the containers between the magazine and the dosage station.

The apparatus generally comprises a box-type holding frame defining afirst chamber, which houses the magazine therein, and is provided withan aperture to allow the operator to load and/or unload the magazine,and a second chamber, which houses the dosage station and the grippingand carrier device therein, is maintained in substantially sterileconditions, and is in communication with the first chamber in order toallow the gripping and carrier device to transfer the containers betweenthe magazine and the dosage station.

The known machines of the above described type have some drawbacksmainly deriving from the fact that, when the first chamber is opened toallow the loading and/or unloading operations of the magazine, the firstchamber is in communication with the external environment totallyexposing the operator to risks correlated to the presence of thecytostatic drugs used in such machines and thus impairing the sterilityof prepared pharmaceutical products.

DISCLOSURE OF INVENTION

It is an object of the present invention to provide a machine for thepreparation of pharmaceutical products which is free from the abovedescribed drawbacks and is simple and cost-effective to be implemented.

According to the present invention there is provided a machine for thepreparation of pharmaceutical products according to the accompanyingclaims.

BRIEF DESCRIPTION OF THE DRAWINGS

The present invention will now be described with reference to theaccompanying drawings, which show an example of non-limitativeembodiment thereof, in which:

FIG. 1 is a diagrammatic front view, with parts removed for clarity, ofa preferred embodiment of the machine of the present invention;

FIG. 2 is a diagrammatic side view, with parts removed for clarity, ofthe machine in FIG. 1;

FIG. 3 is a diagrammatic plan view, with parts removed for clarity, ofthe machine in FIGS. 1 and 2;

FIG. 4 is a perspective view of a first detail of the machine in FIGS.1, 2 and 3;

FIG. 5 is a perspective view of a second detail of the machine in FIGS.1, 2 and 3;

FIG. 6 is a front view of a third detail of the machine in FIGS. 1, 2and 3;

FIG. 7 is a section along line VII-VII of FIG. 6;

FIG. 8 is a perspective view of a fourth detail of the machine in FIGS.1, 2 and 3; and

FIG. 9 is a perspective view of a fifth detail of the machine in FIGS.1, 2 and 3.

BEST MODE FOR CARRYING OUT THE INVENTION

With reference to FIGS. 1 and 3, number 1 indicates, as a whole, amachine for the preparation of pharmaceutical products, in this casetoxic pharmaceutical products as, for example, cytostatic drugs forchemotherapy.

Machine 1 comprises a box-type holding frame 2 having substantiallyparallelepipedal shape, which is delimited by a lower wall 3 and anupper wall 4, which are substantially horizontal and parallel to oneanother, by a front wall 5 and a back wall 6, which are substantiallyvertical and parallel to one another, and by two side walls 7, which aresubstantially parallel to one another and orthogonal to walls 3, 4, 5and 6.

Frame 2 is internally subdivided by an intermediate wall 8, which issubstantially parallel to walls 3 and 4, in an upper chamber 9 and alower chamber 10.

Upper chamber 9 houses therein a magazine 11 for a plurality ofcontainers 12, which will be further shown hereinafter, a dosage station13 for the preparation of the pharmaceutical products, and a grippingand carrier device 14 to displace containers 12 within chamber 9 itself.

Magazine 11 comprises a shaft 15 (FIG. 3), which is rotatably mounted onframe 2 to selectively rotate in intermittent manner with respect toframe 2 and under the drive of a known motor (not shown) about alongitudinal axis 16 thereof parallel to a substantially verticaldirection 17, is housed inside a holding cylinder 18 coaxial to axis 16,and carries a disk 19—splined to an upper free end thereof—which isorthogonally mounted to axis 16, and supports a plurality of grippingand carrier units 20 (in this case nine units 20) uniformly distributedaround axis 16 itself.

With reference to FIG. 4, each unit 20 comprises a hooking plate 21,which is fixed over disk 19, and is provided with a resting block 22that extends upwards from plate 21, and is provided in this case withthree seats 23 for respective glass bottles of the known type (hereafterindicated with 12 a).

Plate 21 also displays three elongated rods 24, which extend downwardsfrom plate 21 through disk 19, are substantially parallel to direction17, and are provided with respective seats 25 for respective knownsyringes (hereafter indicated with 12 b) of different diameter andlength, each of which comprises a holding cylinder 26, which is closedat one end by a needle 27 provided with a protection cap 28, and isslidingly engaged by a piston 29 provided with a head 30 which issubstantially flat and orthogonal to piston 29 itself.

Each seat 25 comprises two gripping elements 31, which substantiallyhave the shape of a fork, are axially spaced along corresponding rod 24,and reciprocally cooperate to receive and hold the corresponding syringe12 b, which is inserted in elements 26 in a transverse direction to axis16 and with needle 27 facing upwards.

At least one of the rods 24 is also provided with a support element 32displaying a bore 33, which is obtained through element 32 parallelly todirection 17, and is adapted to house therein a needle of the known type(not shown), the use of which will be further described hereinafter.

Plate 21 is further provided with a bracket (not shown), which extendsdownwards from plate 21 through disk 19, is substantially parallel todirection 17, and supports at a lower free end thereof a pocket 34,which is radially open towards the outside in order to be slidinglyengaged by an adapter member 35 mounted on a plastic material bag of theknown type (hereinafter indicated with 12 c) provided with two necks 36for the transfer of fluids from and to bag 12 c itself.

According to FIG. 5, member 35 comprises two substantially flat profiledjaws 37, 38, which have a thickness substantially thinner than thelength of a neck 36, and are reciprocally hinged to rotate one withrespect to the other about an axis 39 substantially perpendicular tojaws 37, 38 between a clamping position (not shown) and a releaseposition (FIG. 5) of the two necks 36 themselves.

Jaws 37, 38 are locked in the clamping position by means of a lockingdevice 40 comprising a crank 41 hinged to jaw 37 in order to swing withrespect to jaw 37 itself about an axis 42 parallel to axis 39, and a pin43, which is mounted through crank 41 parallelly to axes 39 and 42 andis displaced by crank 41 between a release position (FIG. 5) and alocking position (not shown), in which crank 41 is displaced through aslit 44 obtained through jaw 38 to engage pin 43 in a seat 45 obtainedon jaw 38.

With reference to FIGS. 1, 3 and 6, dosage station 13 comprises asubstantially flat turntable 46, which is rotatably coupled to frame 2in order to rotate with respect to frame 2 and under the drive of aknown motor (not shown) about a rotation axis 47 parallel to a direction48 which is horizontal and transverse to direction 17, and supports agripping device 49 adapted to receive and hold three syringes 12 bhaving different diameters and lengths.

According to FIGS. 6 and 7, device 49 comprises a slide 50, whichextends in a direction 51 which is horizontal and orthogonal todirections 17 and 48, is coupled in a known manner to turntable 46 inorder to carry out rectilinear displacements in direction 17 withrespect to turntable 46 and under the drive of a known motor (notshown), and in this case is provided with three gripping elements 52distributed along slide 50 in direction 51.

Each element 52 protrudes from slide 50 in direction 48 and cooperateswith two gripping elements 53, which protrude from turntable 46 indirection 48, are aligned with element 52 in direction 17, and havesubstantially the shape of a fork adapted to receive and hold cylinder26 of a corresponding syringe 12 b. Element 52 comprises two jaws 54,55, which are flat and orthogonal to direction 17, and among which jaw54 is arranged between jaw 55 and gripping elements 53 and hassubstantially the shape of a fork adapted to receive the piston 29 ofcorresponding syringe 12 b.

While in use, syringe 12 b is mounted on turntable 46 with needle 27facing downwards and, therefore, during the insertion of syringe 12 b ingripping device 49, turntable 46 is arranged with elements 53 underelement 52 (FIGS. 6 and 7).

The correct insertion of piston 29 inside jaw 54 is assured by adetecting device 56 comprising a substantially flat shoe 57, which ismounted between jaws 54, 55, and is slidingly coupled to jaw 55 in orderto carry out rectilinear displacements in direction 17 with respect tojaw 55 and by modes which will be further illustrated hereinafter.

During insertion of piston 29 inside jaw 54 in direction 48, head 30 ofpiston 29 engages a sphere 58 protruding from shoe 57 in direction 17 soas to raise shoe 57 in direction 17 itself. When the insertion of piston29 and head 30 in jaw 54 is correctly completed, shoe 57 is loweredagain by gravity in its starting position, whereas, when the insertionof piston 29 and head 30 in jaw 54 is not correctly completed, shoe 57remains raised under the thrust of head 30 itself.

The position of shoe 57 in direction 17 is detected by a photoelectriccell 59, which is mounted on turntable 46, is aligned with syringe 12 bin direction 17, and is also adapted to detect while in use the positionof piston 29 in direction 17 itself.

According to a variant not shown, jaws 54, 55 are eliminated andreplaced by two jaws slidingly coupled to slide 50 so that they aredisplaced one with respect to the other in direction 17 between arelease position and a clamping position of head 30 of syringe 12 b.

With reference to FIGS. 1 and 3, gripping and carrier device 14 isdefined by a known-type robot comprising a plurality of reciprocallyhinged articulated arms and a gripping clamp mounted on the free end ofthe articulated arms and configured so as to grab bottles 12 a, syringes12 b, and adapter members 35 of bags 12 c.

Lower chamber 10 houses therein an electronic control unit 60 for theoperation of machine 1, and a collection device 61 for the processingwaste of machine 1. Device 61 is arranged at dosage station 13, andcommunicates with upper chamber 9 through aperture 62 (FIG. 3), which isobtained through intermediate wall 8 parallelly to direction 17, and isprovided with a horizontal shutter (not shown), which is mobile betweenan opening position and a closure position of aperture 62 itself.

According to FIG. 8, device 61 comprises a vertical slide 63, which iscoupled in a known manner to frame 2 in order to carry out rectilineardisplacements in direction 17 with respect to frame 2 and under thedrive of a known-type motor, and is limited in direction 51 by two sidepanels 64 defining a seat for a vessel 65. Vessel 65 is arranged betweenpanels 64 and under aperture 62 with its concavity facing upwards, andis locked on the slide 63 in direction 48 by means of stop members 66hinged to slide 63 in order to swing with respect to slide 63 itself,about respective fulcrum axes 67, which are parallel to direction 51.

Device 61 also comprises a horizontal slide 68, which is coupled in aknown manner to frame 2 in order to carry out rectilinear displacementsin direction 48 with respect to frame 2 and under the drive of aknown-type motor, and is provided with a pair of equalizers 69, whichare hinged to slide 68 and are mobile from and to a hooking position ofa closing lid 70 of vessel 65.

Lid 70 protrudes downwards from slide 68, has a peripheral edge 70 aprovided with an adhesive compound, and is normally arranged by the sideof vessel 65 to allow vessel 65 itself to be arranged in a raisedworking position (not shown).

Device 61 also comprises a known sensor (not shown) to control thefilling level of the vessel 65.

While in use, once the vessel 65 has been filled and lowered, lid 70 isdisplaced in direction 48 over vessel 65, and vessel 65 is raised againin order to allow edge 70 a to engage a corresponding peripheral edge 65a of vessel 65 and to allow lid 70 to hermetically seal the vessel 65itself.

With reference to FIGS. 1 and 2, upper chamber 9 is in communicationwith the external environment through aperture 71, which is obtainedthrough frame 2 in direction 48 in order to allow the operators to gainaccess to magazine 11, is associated to a vertical shutter (not shown),which is mobile in direction 51 between an opening position and aclosure position of aperture 71 itself, and is limited below by a table72 defining a substantially horizontal resting base for bottles 12 a,syringes 12 b, bags 12 c, and the needles (not shown) which need to beloaded on, or unloaded from, magazine 11.

Upper chamber 9 is maintained in substantially sterile conditionsthrough a pneumatic device 73, which is configured so as to supply asterile air flow through chamber 9 in order to prevent the entry of airfrom the external environment into chamber 9 through aperture 71, and toprevent the exit of the sterile air flow from chamber 9 through aperture71 itself, and comprises a ring pneumatic circuit 74 and a fan wheel 75housed in lower chamber 10 to assure the air circulation along circuit74 itself.

Circuit 74 comprises a chamber 76, which is mounted on upper wall 4 offrame 2, is connected to fan wheel 75 by means of a conduit 77, and isin communication with upper chamber 9 by means of the interposition oftwo pairs (only one of which is shown in FIG. 2) of sterilising filters78 of the known type, mounted on chamber 76 at magazine 11 and,respectively, at dosage station 13; an outlet 79, that is incommunication with the external environment, and is also connected tochamber 76 by means of the interposition of a sterilising filter 80 ofthe known type; and a valve 81 of the known type to selectively controlthe air flow rate supplied to the outlet 79.

The sterile air flow supplied inside upper chamber 9 is partly divertedtowards aperture 71 by means of a first diverting element 82, which isprofiled so as to create a sterile air barrier at aperture 71 itself,which descends from above towards table 72 to prevent the entry of airinto upper chamber 9 from the external environment.

Circuit 74 also comprises a second diverting element 83 having asubstantially cylindrical shape, which is mounted on, and connects to,table 72, and is adapted to divert towards upper chamber 9 the sterileair flow descending so as to carry out the cleaning of table 72 andprevent the exit of air from chamber 9 itself.

Circuit 74 is also provided with a third diverting element 84 havingsubstantially cylindrical shape, which is mounted under table 72 on theopposite band with respect to element 83 in direction 48, is connectedto table 72, has in this case a radium of curvature smaller than theradium of curvature of element 83, and is adapted to divert the sterileair flow inside an inclined conduit 85 which extends under table 72, isin communication with fan wheel 75 by means of the interposition of asterilising filter 86, and shows an inlet 87 communicating with theexternal environment in order to intake from the external environment anair flow rate substantially equal to the air flow rate discharged in theexternal environment itself through outlet 79.

A first operation mode will now be described with reference to theaccompanying drawings, assuming the production of a singlepharmaceutical product, and starting from a time at which:

seats 23 are loaded partly with bottles 12 a containing a diluent as,for example, a physiological or glucosated solution, partly with bottles12 a containing a liquid cytostatic compound, and partly with bottles 12a containing a cytostatic powder compound;

seats 25 are loaded with respective empty syringes 12 b;

pockets 34 are loaded with respective bags 12 c provided withcorresponding adapter members 35 containing a diluent as, for example, aphysiological or glucosated solution;

support elements 32 are loaded with respective needles (not shown); and

vessel 65 of collection device 61 is raised near aperture 62.

The presence of syringes 12 b and bags 12 c in corresponding seats 25and, respectively, in corresponding pockets 34 is controlled by means ofcorresponding known photoelectric cells (not shown) mounted on shaft 15and facing towards corresponding slits (not shown) radially obtainedthrough holding cylinder 18; and the presence of bottles 12 a in thecorresponding seats 23 is controlled by means of correspondingphotoelectric cells mounted over disk 19.

The identification of syringes 12 b and bags 12 c loaded in thecorresponding seats 25 and, respectively, in the corresponding pockets34 is carried out by displacing the magazine around axis 16 and in frontof a bar code reader (not shown) fixed to frame 2.

Gripping and carrier device 14 firstly withdraws a syringe 12 b fromcorresponding seat 25, then inserts the syringe 12 b in gripping device49 with needle 27 facing downwards (FIGS. 1, 6 and 7), and finallyremoves the cap 28 from the needle 27 itself; and the turntable 46 isrotated by 180° in order to position syringe 12 b with needle 27 facingupwards.

Device 14 therefore withdraws a bottle 12 a containing a liquidcytostatic compound from the corresponding seat 23 and arranges it on aturntable 88 (FIG. 3), which is rotatably mounted on frame 2 in order torotate with respect to frame 2 and under the drive of a known motor (notshown) about a rotation axis 89 parallel to direction 17, and forms partof an identification device 90 of the known type further comprising alight source (not shown) and a camera (not shown) adapted to carry outthe scanning of a label applied on the bottle 12 a itself.

Obviously, the identification of bottles 12 a, syringes 12 b, and bags12 c may be carried out by means of bar codes, labels, RFID tags, orother identifying elements applied on containers 12.

Once identified by device 90, bottle 12 a taken in consideration isfirstly weighted on a scale 91 of the known type, is then transferred ata seal-remover device 92 (FIGS. 1 and 3) of the known type adapted toremove the metal seal (not shown) normally applied on the elasticmembrane (not shown) of bottles 12 a and to unload the metal seal itself(not shown) in vessel 65 through aperture 62, and is finally reversedonto syringe 12 b in engagement with needle 27.

At this point, slide 50 is lowered in direction 17 in order to allow jaw54 to lower piston 29 along cylinder 26 under the control of thecorresponding photoelectric cell 59 and to allow syringe 12 b towithdraw from bottle 12 a a determined amount of liquid cytostaticcompound; bottle 12 a is disengaged from needle 27, and unloaded invessel 65 or transferred on a resting shelf (not shown) or transferredagain to magazine 11; and turntable 46 is rotated by 180° to positionsyringe 12 b with needle 27 facing downwards again.

Thereafter, device 14 withdraws a new bottle 12 a containing a diluentfrom magazine 11, and the bottle 12 a is identified by device 90, isweighted on scale 91, is transferred to seal-remover device 92 for theremoval of the corresponding metal or plastic seal, and is finallydisplaced under syringe 12 b in engagement with needle 27.

Finally, slide 50 is lowered in direction 17 in order for jaw 55 toengage head 30 by means of slide 57 so as to lower piston 29 alongcylinder 26 under the control of the corresponding photoelectric cell 59and to inject the liquid cytostatic compound contained in syringe 12 bin the new bottle 12 a; bottle 12 a with the freshly preparedpharmaceutical product is disengaged from needle 27, weighted on scale91, and transferred to magazine 11 so it may be withdrawn by theoperator; and syringe 12 b is unloaded in vessel 65.

A second operation mode differs from that set forth above only in thatboth the liquid cytostatic compound and the diluent are withdrawn bysyringe 12 b and syringe 12 b containing the freshly preparedpharmaceutical product is transferred to magazine 11 so it may bewithdrawn by the operator. Obviously, the diluent may be withdrawn bothfrom a bottle 12 a and from a bag 12 c.

A third operation mode differs from that set forth above only in thatthe pharmaceutical product is prepared in a bag 12 c.

In this case, bag 12 c taken in consideration is firstly withdrawn frommagazine 11 by means of device 14, is then weighted on scale 91, and isfinally transferred to a pumping device 93 (FIG. 3), which has beenequipped with the needle (not shown) of one of support elements 32 towithdraw from bag 12 c an amount of diluent substantially equal to theamount of cytostatic compound to be injected in the bag 12 c itself.

In order to allow pumping device 93 to correctly withdraw the diluent,bag 12 c is rested in downwardly inclined position over a pair of pins(not shown) protruding from frame 2 in direction 51, jaws 37, 38 ofadapter member 35 are engaged in a pair of pins (not shown) protrudingfrom pumping device 93 in direction 48, and the needle (not shown) ofpumping device 93 itself is engaged in one of necks 36 of bag 12 c.

Once the withdrawal of diluent is completed, bag 12 c is firstlytransferred from device 14 to dosage station 13 in order to receive thecytostatic compound from syringe 12 b and then to magazine 11 so it maybe withdrawn by the operator.

A fourth operation mode differs from that previously set forth only inthat the pharmaceutical product is manufactured using a powder orlyophilised cytostatic compound.

In this case, syringe 12 b firstly withdraws a determined amount ofdiluent from a corresponding bottle 12 a or from a corresponding bag 12c, and then injects the diluent in bottle 12 a containing the powder orlyophilised cytostatic compound.

At this point, bottle 12 a containing the diluent and the powder orlyophilised cytostatic compound is transferred from device 14 to a mixerdevice 94 in order to mix the diluent and the cytostatic compoundtogether.

With reference to FIG. 9, device 94 comprises a support plate 95, whichis fixed to the intermediate wall 8 of frame 2, is limited above by asurface 96 inclined with respect to direction 17, and supports arotating plate 97 coupled in a known manner to support plate 95 in orderto rotate clockwise and/or anti-clockwise with respect to support plate95 and under the drive of a known motor (not shown) about an axis 98arranged by an angle other than 90° with respect to wall 8.

Plate 97 comprises a plurality of seats 99 (in this case four seats 99),which are adapted to house therein corresponding bottles 12 a (evenhaving different size from one another), are distributed uniformlyaround axis 98, and extend transversely to axis 98 itself.

Each seat 99 is circumferentially limited by two side walls 100substantially parallel to one another and transverse to axis 98, and isalso radially limited by an external end-stop element 101 mounted on theperipheral edge of plate 97 parallelly to axis 98 and by an internalend-stop element 102, which is common to all of seats 99, and is mountedat the centre of plate 97 coaxially to axis 98.

A plurality of annular rubber elements 103 is mounted on upper surface96 of support plate 95 (in this case four elements 103), which arecoaxial to one another and to axis 98, extend around axis 98 accordingto an angle sharper than 360° so as to define a free portion of surface96, and engage corresponding slits 104 obtained through a bottom wall105 of each seat 99 parallelly to axis 98.

While in use, during the rotation of plate 97 about axis 98, thefriction occurring between elements 103 and bottles 12 a housed in seats99 determines a rotation of each bottle 12 a about a longitudinal axis Athereof. The combination of the rotation of plate 97 about axis 98 andthe rotation of each bottle 12 a about corresponding axis A increasesthe efficacy of mixing device 94.

The rotation of plate 97 about axis 98 is controlled so as to stop plate97 each time with seat 99 of bottle 12 a to be withdrawn always arrangeddownwards and at the free portion of surface 96, that is, at the portionof surface 96 not carrying elements 103. In this manner, bottle 12 a tobe withdrawn is always arranged in the same position, that is at thecentre of corresponding seat 99 and in contact with correspondingexternal end-stop element 101, so as to allow a correct withdrawal ofbottle 12 a itself by device 14.

Freshly mixed bottles 12 a may thus be used in any of the threeoperation modes previously described.

Finally, it should be noted that at completion of the maintenanceoperation of machine 1, upper chamber 9 is sterilised by means of aplurality of known UV lamps (not shown) fixed to frame 2.

According to a variant not shown, with machine 1, it is also possible touse plastic material bottles provided with a single neck virtuallysimilar to necks 36 and with an adapter member virtually similar tomembers 35.

In this case, device 14 withdraws a bag 12 c from magazine 11 andtransfers it to dosage station 13, at which a syringe 12 b withdraws adetermined amount of diluent of bag 12 c itself.

Device 14 therefore withdraws the above mentioned bottle, transfers itto dosage station 13, at which syringe 12 b injects the diluent that hasbeen freshly withdrawn from bag 12 c, and places it on a resting shelf.

Thereafter, device 14 unloads syringe 12 b in vessel 65, and transfers anew syringe 12 b from magazine 11 to station 13, at which syringe 12 bitself withdraws a determined amount of liquid cytostatic compound frombottle 12 a.

Finally, the freshly withdrawn cytostatic compound is injected in thebottle which has been previously placed on the resting shelf, and thebottle is transferred again to magazine 11 so it may be withdrawn by theoperator.

1. A machine for the preparation of pharmaceutical products comprising amagazine for a plurality of containers, each container of at least partof the containers containing a pharmaceutical compound and/or a diluent;a dosage station for the preparation of a pharmaceutical productcomprising at least one said pharmaceutical compound and at least onesaid diluent; gripping and carrier means to transfer the containersbetween the magazine and the dosage station; a box-type holding framedefining a chamber for the housing of the magazine, the dosage station,and the gripping and carrier means; and a pneumatic device to supply asterile air flow through the entire said chamber; wherein the chamberdisplays an access aperture to the magazine; the pneumatic devicecomprising a pneumatic circuit configured so as to generate a sterileair barrier at said aperture, adapted to prevent the entry in thechamber of air from the external environment.
 2. The machine accordingto claim 1, wherein the pneumatic circuit extends along a ring path; thepneumatic device also comprising supplying means to push the air alongthe pneumatic circuit itself.
 3. The machine according to claim 1,wherein the pneumatic device also comprises first diverting means todivert at least part of said sterile air flow towards said aperture soas to generate said sterile air barrier.
 4. The machine according toclaim 1, wherein the pneumatic device further comprises second divertingmeans to prevent the exit of the sterile air flow to the externalenvironment through said aperture.
 5. The machine according to claim 1,wherein the pneumatic device further comprises first diverting means todivert at least part of said sterile air flow towards said aperture soas to generate said sterile air barrier and second diverting means toprevent the exit of the sterile air flow to the external environmentthrough the aperture itself; said first and second diverting means beingarranged on opposite bands of said aperture in a direction of forwardmotion of the air along the pneumatic circuit.
 6. The machine accordingto claim 4, wherein the pneumatic circuit comprises an inletcommunicating with the external environment and arranged at saidaperture.
 7. The machine according to claim 6, wherein the seconddiverting means comprise a first diverting surface to prevent the exitof sterile air flow to the external environment through said aperture.8. The machine according to claim 7, wherein the second diverting meansfurther comprise a second diverting surface to divert the air towardssaid inlet from said first diverting surface.
 9. The machine accordingto claim 8, wherein said first and second diverting surfaces aresubstantially cylindrical.
 10. The machine according to claim 9, whereinthe first diverting surface displays a radium of curvature greater thanthe radium of curvature of the second diverting surface.
 11. The machineaccording to claim 8, wherein said aperture is provided with supportmeans defining a resting base for the containers to be transferred fromand to the magazine; the resting base being connected to said first andsecond diverting surfaces.
 12. The machine according to claim 11,wherein said inlet is arranged under said resting base.
 13. The machineaccording to claim 6, wherein the pneumatic circuit further comprises anoutlet to discharge air from the pneumatic circuit to the externalenvironment.
 14. The machine according to claim 13, wherein said inletand outlet are configured such that the air flow rate supplied insidethe pneumatic circuit through said inlet is substantially equal to theair flow rate released to the external environment through said outlet.15. The machine according to claim 6, wherein the pneumatic devicefurther comprises a first filtering device to filter the air supplied inthe pneumatic circuit through said inlet.
 16. The machine according toclaim 2, wherein the pneumatic device further comprises a secondfiltering device arranged between said supplying means and said chamberto filter the air supplied to the chamber itself.
 17. The machineaccording to claim 13, wherein the pneumatic device further comprises athird filtering device arranged between said supplying means and saidoutlet to filter the air supplied to the outlet itself.
 18. The machineaccording to claim 13, wherein the pneumatic device further comprisesvalve means arranged along the pneumatic circuit to selectively controlthe supply of air to said outlet and chamber.
 19. A machine for thepreparation of pharmaceutical products comprising a magazine for aplurality of containers, each container of at least part of thecontainers containing a pharmaceutical compound and/or a diluent; adosage station for the preparation of a pharmaceutical productcomprising at least one said pharmaceutical compound and at least onesaid diluent; gripping and carrier means to transfer the containersbetween the magazine and the dosage station; and collection means forthe processing waste of the machine, the collection means comprising avessel and a closing lid for the vessel itself; and wherein thecollection means further comprise actuating means to displace the vesseland the lid one with respect to the other in two directions which aresubstantially transverse to one another.
 20. The machine according toclaim 19, wherein one said first direction is substantially vertical.21. The machine according to claim 19, wherein one said second directionis substantially horizontal.
 22. The machine according to claim 19,wherein the vessel and the lid display corresponding peripheral edgesadapted to come into contact with one another following a displacementof the vessel and of the lid in a closure position of the vessel itself;at least one of said edges being provided with a sealing compound. 23.The machine according to claim 19, wherein said collection means furthercomprise first and second support means for said vessel and respectivelyfor said lid.
 24. The machine according to claim 19, wherein thecollection means further comprise detecting means to detect the fillinglevel of said vessel.
 25. The machine according to claim 19, furthercomprising a chamber for the housing of the magazine, the dosagestation, and the gripping and carrier means, a partition wall toseparate the chamber and said collection means from one another, and anaperture obtained through the partition wall to connect the chamber andthe collection means to one another.
 26. The machine according to claim25, further comprising a closure device, which is mobile between anopening position and a closure position of said aperture.
 27. A machinefor the preparation of pharmaceutical products comprising a magazine fora plurality of containers, each container of at least part of thecontainers containing a pharmaceutical compound and/or a diluent; adosage station to prepare within a first said container a pharmaceuticalproduct comprising at least one said pharmaceutical compound and atleast one said diluent; gripping and carrier means to transfer thecontainers between the magazine and the dosage station; and mixing meansto mix said first container so as to mix the pharmaceutical compound andthe diluent, the mixing means comprising a rotating plate, whichdisplays a first determined longitudinal axis and is provided with atleast one seat for said first container, and first actuating means torotate the rotating plate about said first axis; and wherein the mixingmeans further comprise second actuator means to rotate said firstcontainer about a determined second longitudinal axis (A) thereof duringat least part of the rotation of the rotating plate about said firstaxis.
 28. The machine according to claim 27, wherein said first axis isarranged according to an angle other than 90° with respect to asubstantially horizontal datum plane.
 29. The machine according to claim27, wherein said second actuator means comprise at least one fixedactuator member arranged in contact with said first container to rotateby friction the first container itself about said second axis (A). 30.The machine according to claim 29, wherein the actuator member comprisesan annular element extending around said first axis.
 31. The machineaccording to claim 30, wherein the annular element extends around saidfirst axis by an angle sharper than 360°.
 32. The machine according toclaim 30, wherein the mixing means further comprise a support plate,which is rotatably engaged by the rotating plate and supports saidannular element; said seat displaying at least one slit obtained throughthe rotating plate and engaged by the annular element.
 33. The machineaccording to claim 30, wherein said second actuator means comprise aplurality of said annular elements concentrically mounted to oneanother; said seat displaying a corresponding slit for each annularelement, obtained through the rotating plate and engaged by annularelement itself.
 34. The machine according to claim 27, wherein therotating plate is provided with a plurality of said seats distributedaround said first axis.
 35. The machine according to claim 27, whereinsaid pharmaceutical compound is a powder or lyophilised pharmaceuticalcompound.
 36. A machine for the preparation of pharmaceutical productscomprising a magazine for at least one container, which displays atleast one neck for the transfer of fluids from and to container, and isprovided with an adapter member mounted on the neck itself; a dosagestation for the preparation of a pharmaceutical product comprising atleast one pharmaceutical compound and at least one diluent; and grippingand carrier means adapted to grab the adapter member to transfer thecontainer between the magazine and the dosage station; and wherein theadapter member comprises two jaws, which are mobile between a clampingposition and a release position of said neck, and locking means to lockthe jaws themselves in said clamping position.
 37. The machine accordingto claim 36, wherein said jaws display a thickness thinner than thelength of said neck.
 38. The machine according to claim 36, wherein saidlocking means comprise a seat, which is obtained in a first said jaw,and a locking member, which is carried by a second said jaw and ismobile from and to an engagement working position of the seat itself.39. The machine according to claim 36, wherein the jaws are reciprocallyhinged to rotate one with respect to the other about a determinedfulcrum axis.
 40. The machine according to claim 39, wherein the lockingmeans comprise a seat obtained in a first said jaw, a pin which issubstantially parallel to said fulcrum axis, and a support crank for thepin, which is hinged to a second said jaw to displace the pin itselffrom and to an engagement working position of said seat.
 41. The machineaccording to claim 36, wherein at least one of the jaws is configured tobe coupled with at least one support device.
 42. The machine accordingto claim 36, wherein said container is a plastic material bag.
 43. Themachine according to claim 36, wherein said container is a plasticmaterial bottle.